Press "Enter" to skip to content

Alternative Splicing and Disease by Laurent Bracco, Emeline Throo, Olivier Cochet (auth.),

By Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)

Splicing of basic RNA transcript, i.e. removing of introns and becoming a member of of exons to provide mature mRNAs powerfuble for translation into proteins, is a quasi-systematic step of gene expression in greater organisms. even if, this technique isn't unequivocal yet can persist with trade pathways. substitute splicing of a given transcript can for that reason yield numerous designated mRNAs encoding as many alternative proteins. Its complete organic value has now not been liked till it used to be famous that substitute splicing is so basic as to impact approximately seventy five% of all human genes. for this reason, substitute splicing not just enormously raises protein range but in addition bargains various possibilities for aberrant splicing occasions with pathological consequences.

Show description

Read Online or Download Alternative Splicing and Disease PDF

Best nonfiction_9 books

Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines

Content material: PREFACE ; 1. contemporary BIOTECHNOLOGICAL purposes OF GLYCO-NANOMATERIALS ; SUNG YOU HONG, MALCOLM L. H. eco-friendly, AND BENJAMIN G. DAVIS ; 2. FUNCTIONALIZED GLYCONANOPARTICLES FOR THE learn OF GLYCOBIOLOGY ; WEI-TING CHIEN, CHING-CHING YU, CHIEN-FU LIANG, CHIAN-HUI LAI, PO-CHIAO LIN, AND CHUN-CHENG LIN ; three.

Primary Brain Tumors: A Review of Histologic Classification

This quantity represents the formal displays and discussions which came about in the course of a three-day assembly in March 1988 on the collage of Texas M. D. Anderson melanoma heart in Houston. it truly is" devoted to my good friend of greater than thirty years, Prof. Dr. Klaus Joachim Ziilch, who died in Berlin on December 2.

Oppenheimer's Diagnostic Neuropathology: A Practical Manual

Oppenheimers Diagnostic Neuropathology, a pragmatic handbook has develop into a contemporary vintage in its box, masking the sensible features of the paintings of the neuropathologist. filled with brilliant suggestion and observations usually passed over from neuropathology texts, it publications the neuropathologist throughout the equipment on hand to them whilst dealing with diagnostic questions.

Extra info for Alternative Splicing and Disease

Example text

This indicates that the proper concentration of regulatory factors is necessary for cell survival. However, the loss of splicing factors in differentiated cells can be tolerated and leads to specific phenotypes (Xu et al. 2005). Mutations in proteins implicated in splicing have been observed in retinitis pigmentosa, a progressive loss of photoreceptor cells during childhood, where PRP31 is mutated (Vithana et al. 2001) and forms of azospermia, where RBMY has been deleted (Venables et al. 2000).

J Mol Cell Cardiol 38: 485–493 Saccomanno CF, Bordonaro M, Chen JS, Nordstrom JL (1992) A faster ribonuclease protection assay. Biotechniques 13: 846–850 Samowitz WS, Thliveris A, Spirio LN, White R (1995) Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC. Cancer Res 55: 3732–3734 Scaffidi P, Misteli T (2005) Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 11: 440–445 Schadt EE, Edwards SW, Guha Thakurta D, Holder D, Ying L, Svetnik V, Leonardson A, Hart KW, Russell A, Li G, Cavet G, Castle J, McDonagh P, Kan Z, Chen R, Kasarskis A, Margarint M, Caceres RM, Johnson JM, Armour CD, Garrett-Engele PW, Tsinoremas NF, Shoemaker DD (2004) A comprehensive transcript index of the human genome generated using microarrays and computational approaches.

1994) CTTATGAACGACTGG CTTATGAATGACTGG GGGCGCTGG GGGCACTGG GGGGAGTGAGACTTC Llewellyn et al. (1996) Liu et al. (1997) Chen et al. (1998) Ferrari et al. (2001) Hasegawa et al. (1994) Gu et al. (2001) GTGATTCGCGTGGGT GTGATTCGGGTGGGT Porphobilinogen deaminase Fumarylacetoacetate hydrolase Pyruvate dehydrogenase E1 alpha TNFRSF5, tumorCTACAGGG necrosis factor CTACTGGG receptor superfamily, member 5 (CD40); CCTATGGGCCGTT CYP27A1 CCTATGTGCCGTT GGGATCATCGTGGGA Fibrillin-1 GGGATCATTGTGGGA MNK Menkes disease Bardet-Biedl Syndrome MGC1203 Zavadakova et al.

Download PDF sample

Rated 4.22 of 5 – based on 20 votes