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Advances in Blood Substitutes: Industrial Opportunities and by Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim

By Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim D. Vandegriff Ph.D., Marcos Intaglietta Ph.D. (eds.)

Each bankruptcy of this quantity is a contribution from knowledgeable within the box, selected by means of the editors to give a contribution to the 1997 "Current matters in Blood replacement learn and improvement" path given in San Diego, March 17-19. The members have been chosen due to their services in parts which the editors think to be serious to the development of the sector, and which replicate job in "hot" parts of proper examine. whereas there's a continuity well-liked for the once a year path, every year brings alterations in emphasis and content material. In past years, we have been frequently unable to supply time for members to offer their perspectives and evaluations. as a result, this 12 months we inspired dialogue after each one presentation. those periods have been recorded, transcribed, and are published with the chapters herein. We think that the product is especially just about the shooting this year's path in print, and belief readers will take pleasure in examining the continuously candid and infrequently provocative feedback from the viewers. the associated fee paid for inclusion of the dialogue transcriptions used to be a hold up in booklet. every one writer was once allowed to edit his/her dialogue part in addition to the ultimate model of the chapters sooner than e-book. The alterations are in general for grammar, and we attempted, whilst attainable, to not modify the conversational variety of those interchanges.

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W. Furlong, D. Feeny, and M. Boyle. Multi-attribute preference functions, health utilities index. PharmacoEconomics 7: 503520,1995. M. Ryan. Strategic planning for applied pharmacoeconomics programs. Pharmacy Practice Management Quarterly 15: 64-74, 1996. Chapter 4 Tumor Microcirculation: Role in Drug and Nutrient Delivery Rakesh K. D. ABSTRACT To reach cancer cells in a tumor, a blood-borne molecule must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium.

1996, Hillman and Kim 1995, Mauskopf et al. 1996, Rutten-van Molken, van Doorslaer and van Vliet 1994, Task Force on Principles for Economic Analysis of Health Care Technology 1995, Torrance et al. 1996, Torrance et al. 1995). Below, the pharmacoeconomic study design is very briefly highlighted. 40 Bassett The economic analysis of a new therapeutic agent will ideally cover three areas. First, the impact of health-services resources must be examined, including the costs associated with the new therapeutic as well as the savings of resources that may result from discontinued therapies as a result of using the new agent.

1994b). Furthermore, RBC velocity may be an order of magnitude lower in tumors compared to the host vessels. 1) may, in part, be a result of elevated geometric and viscous resistance in tumor vessels (Less et al. 1997, Sevick and Jain 1989a, Sevick and Jain 1989b, Sevick and Jain 1991a), coupling between high vascular permeability and elevated interstitial fluid pressure (Netti et al. 1996), and vascular remodeling by intussusception (Patan, Munn and Jain 1996). 49 Tumor Microcirculation: Role in Drug and Nutrient Delivery V max (mmls) 35 Arterioles Venules 30 • • 25 • • ..

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